Drs Samuel Klempner and Nataliya Uboha discuss the treatment of patients with locally advanced esophageal adenocarcinomas who opt to not undergo esophagostomy.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999885. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Esophageal Cancer https://emedicine.medscape.com/article/277930-overview

Ten-Year Outcome of Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal Cancer: The Randomized Controlled CROSS Trial https://pubmed.ncbi.nlm.nih.gov/33891478/

A Review of Circulating Tumor DNA in the Diagnosis and Monitoring of Esophageal Cancer https://pubmed.ncbi.nlm.nih.gov/35210388/

Predictive Value of PD-L1 Expression in Response to Immune Checkpoint Inhibitors for Esophageal Cancer Treatment: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/36591463/

Phase III, Randomised Trial of Avelumab Versus Physician's Choice of Chemotherapy as Third-line Treatment of Patients With Advanced Gastric or Gastro-esophageal Junction Cancer: Primary Analysis of JAVELIN Gastric 300 https://pubmed.ncbi.nlm.nih.gov/30052729/

Assessment of Ramucirumab Plus Paclitaxel as Switch Maintenance Versus Continuation of First-line Chemotherapy in Patients With Advanced HER2-Negative Gastric or Gastroesophageal Junction Cancers: The ARMANI Phase III Trial https://pubmed.ncbi.nlm.nih.gov/30922323/

Study Protocol for the OligoMetastatic Esophagogastric Cancer (OMEC) Project: A Multidisciplinary European Consensus Project on the Definition and Treatment for Oligometastatic Esophagogastric Cancer https://pubmed.ncbi.nlm.nih.gov/36184420/

The RENAISSANCE (AIO-FLOT5) Trial: Effect of Chemotherapy Alone vs. Chemotherapy Followed by Surgical Resection on Survival and Quality of Life in Patients With Limited-Metastatic Adenocarcinoma of the Stomach or Esophagogastric Junction - a Phase III Trial of the German AIO/CAO-V/CAOGI https://pubmed.ncbi.nlm.nih.gov/29282088/

EA2183: A Phase III Study of Consolidative Radiotherapy in Patients With Oligometastatic HER2-Negative Esophageal and Gastric Adenocarcinoma https://ascopubs.org/doi/10.1200/JCO.2022.40.16_suppl.TPS4162